✦ LIBER ✦

2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as Covalent-Binding, Irreversible Inhibitors of the Kinase Domain of Vascular Endothelial Growth Factor Receptor-2

✍ Scribed by Wissner, Allan; Floyd, M. Brawner; Johnson, Bernard D.; Fraser, Heidi; Ingalls, Charles; Nittoli, Thomas; Dushin, Russell G.; Discafani, Carolyn; Nilakantan, Ramaswamy; Marini, Joseph; Ravi, Malini; Cheung, Kinwang; Tan, Xingzhi; Musto, Sylvia; Annable, Tami; Siegel, Marshall M.; Loganzo, Frank

Book ID: 121194207
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 465 KB
Volume: 48
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm050559f

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

7-Substituted-[1, 4]dioxano[2, 3-g]quina

7-Substituted-[1, 4]dioxano[2, 3-g]quinazolines as Inhibitors of Epidermal Growth Factor Receptor Kinase

✍ Jae Yeol Lee; Yong Kyu Park; Seon Hee Seo; Beom-Seok Yang; Hokoon Park; Yong Sup 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB

## Abstract With the aim of developing inhibitors of EGFR tyrosine kinase, the 7‐methoxymethyl‐[1, 4]dioxano[2, 3‐__g__]quinazolines (**3a—b**) and 7‐mono‐ or di‐alkylaminomethyl‐[1, 4]dioxano[2, 3‐__g__]quinazolines (**4a—i**) were prepared and evaluated for the inhibition of EGFR tyrosine kinase

Tyrosine Kinase Inhibitors. 15. 4-(Pheny

Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor

✍ Zhou, Hairong; Showalter, H. D. Hollis; Winters, R. Thomas; Smaill, Jeff B.; Pal 📂 Article 📅 1999 🏛 American Chemical Society 🌐 English ⚖ 253 KB

Design, Synthesis, and Evaluation of Ora

Design, Synthesis, and Evaluation of Orally Active 4-(2,4-Difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1- f ][1,2,4]triazines as Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Inhibitors

✍ Borzilleri, Robert M.; Zheng, Xiaoping; Qian, Ligang; Ellis, Christopher; Cai, Z 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 459 KB

6-Substituted-4-(3-bromophenylamino)quin

6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

✍ Tsou, Hwei-Ru; Mamuya, Nellie; Johnson, Bernard D.; Reich, Marvin F.; Gruber, Br 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 252 KB

1H-1,2,4-Triazol-3-yl-anilines: Novel Po

1H-1,2,4-Triazol-3-yl-anilines: Novel Potent Inhibitors of Vascular Endothelial Growth Factor Receptors 1 and 2

✍ Alexander S. Kiselyov; Evgueni Piatnitski; Daniel Milligan; Xiaohu Ouyang 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB

Tyrosine Kinase Inhibitors. 17. Irrevers

Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2- d ]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions

✍ Smaill, Jeff B.; Rewcastle, Gordon W.; Loo, Joseph A.; Greis, Kenneth D.; Chan, 📂 Article 📅 2000 🏛 American Chemical Society 🌐 English ⚖ 286 KB