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2′-O,4′-C-Ethylene-Bridged Nucleic Acid (ENA) for Effective Antisense Formation

✍ Scribed by Koji Morita; Koji Yamate; Shin-ichi Kurakata; Kenji Watanabe; Takeshi Imanishi; Makoto Koizumi


Publisher
John Wiley and Sons
Year
2004
Weight
57 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract Due to the instability of pyrimidine motif triplex DNA at physiological pH, triplex stabilization at physiological pH is crucial in improving its potential in various triplex‐formation‐based strategies in vivo, such as gene expression regulation, genomic DNA mapping, and gene‐targeted m