The highly stereoselective ring opening of N-tosylaziridine 2-carboxylate esters with LiAIH4 followed by oxidation of the ensuing syn alcohols results in a highly efficient 4 step asymmetric synthesis of a-methyl I~-amino acids from N-sulfinylaziridine 2-carboxylate esters.
✦ LIBER ✦
2-Methyl N-(p-toluenesulfinyl)aziridine-2-carboxylic acid: Asymmetric synthesis of α-methylphenylalanine and α-methyl-β-phenylserine
✍ Scribed by Franklin A. Davis; Hu Liu; G. Venkat Reddy
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 239 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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