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Synthesis of the 2β,3α- and 2β,3β-isomers of 3-(p-substituted phenyl)tropane-2-carboxylic acid methyl esters

✍ Scribed by Kathryn I. Keverline; Philip Abraham; Anita H. Lewin; F.Ivy Carroll


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
183 KB
Volume
36
Category
Article
ISSN
0040-4039

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3β-(p-Trimethylsilylphenyl)tropane-2β-ca
✍ John L. Musachio; Kathryn I. Keverline; F.Ivy Carroll; Robert F. Dannals 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 295 KB

Here we report the synthesis of 3 beta-(p-trimethylsilylphenyl)tropane-2 beta-carboxylic acid methyl ester, a new, easily prepared precursor for the synthesis of radioiodinated versions of RTI-55. In contrast to the 3 beta-(p-trimethylstannylated) precursor for radioiodination, the aryl silane is pr