2-Benzamidoethyl Group − A Novel Type of Phosphate Protecting Group for Oligonucleotide Synthesis
✍ Scribed by Guzaev, Andrei P.; Manoharan, Muthiah
- Book ID
- 118218069
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 149 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0002-7863
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📜 SIMILAR VOLUMES
The utility of the 2-(arylcarbamoyloxy)ethyl group for protection of internucleosidic phosphate linkages in oligonucleotide synthesis was studied. Of the three protecting groups tested, the 2-[(1-naphthyl)carbamoyloxy]ethyl demonstrated high coupling yields, favorable deprotection kinetics and the h
4-Cyano-2-butenyl (CB) is a new type of protecting group for the intemucleotidic bonds in the synthesis of oligodeoxyribonucleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild conditions by a 8-elimination pathway using aqueous ammonium h