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2-Arylamino-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidines: synthesis and diuretic activity

โœ Scribed by Antonio Monge; Victor Martinez-Merino; Carmen Sanmartin; Francisco J Fernandez; Maria C Ochoa; Carlos Bellver; Pedro Artigas; Eldiberto Fernandez-Alvarez

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
638 KB
Volume
24
Category
Article
ISSN
0223-5234

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๐Ÿ“œ SIMILAR VOLUMES

Synthesis and properties of 2-substitute
Synthesis and properties of 2-substituted 1-aryl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidines
โœ L. M. Demina; M. Yu. Gavrilov; M. I. Vakhrin; M. E. Konshin ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer US ๐ŸŒ English โš– 388 KB

Cyclization of 2- (N-acetyl-N-arylamino)nicotinonitriles in the presence of dry HCI gave 1-aryl-2-methyl-4-oxo-l,4-dihydropyrido[2,3-d]pyrimidines. It was shown that they are acylated by acetic anhydride, aroyl chlorides, and phenyl isocyanate at the methyl group and that with benzaldehyde they give