Dimethyleicosatrienoic acids: Inhibitors
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Carl D. Perchonock; Joseph A. Finkelstein; Irene Uzinskas; John G. Gleason; Henr
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Article
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1983
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Elsevier Science
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French
⚖ 190 KB
Syntheses of 7,7-and 10,10-dimethyleicosa-5(Z1,8(Z),ll(Z1-trienoic acids (zand $1, which possess 5-lipoxygenase inhibitory activity, are described. Arachidonic acid (L) is now well established as a key substance in the biosynthesis of the leukotrienes, a family of compounds that have been implicated