2-Alkyl-1-(2-aryl-1,1-difluoro-2-hydroxyethyl)benzimidazoles: potential angiotensin II receptor antagonists

✍ Scribed by Lev M Yagupolskii; Dmitrij V Fedyuk

• Book ID: 104210039
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 91 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00148-9

✦ Synopsis

2-Alkyl-1-(bromodifluoromethyl)benzimidazoles were synthesized and condensed with aromatic aldehydes to give 2-alkyl-1-(2-aryl-1,1-difluoro-2-hydroxyethyl)-benzimidazoles. A potential nonpeptide antagonist of the angiotensin II receptor with the -CF 2 CH(OH)-bridge between the heterocyclic nitrogen atom and the biphenyl moiety was synthesized.