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ChemInform Abstract: 2-Alkyl-1-(2-aryl-1,1-difluoro-2-hydroxyethyl)benzimidazoles: Potential Angiotensin II Receptor Antagonists.

✍ Scribed by Lev M. Yagupolskii; Dmitrij V. Fedyuk

Book ID
101891852
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
31
Category
Article
ISSN
0931-7597

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2-Alkyl-1-(2-aryl-1,1-difluoro-2-hydroxy
2-Alkyl-1-(2-aryl-1,1-difluoro-2-hydroxyethyl)benzimidazoles: potential angiotensin II receptor antagonists
✍ Lev M Yagupolskii; Dmitrij V Fedyuk πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 91 KB

2-Alkyl-1-(bromodifluoromethyl)benzimidazoles were synthesized and condensed with aromatic aldehydes to give 2-alkyl-1-(2-aryl-1,1-difluoro-2-hydroxyethyl)-benzimidazoles. A potential nonpeptide antagonist of the angiotensin II receptor with the -CF 2 CH(OH)-bridge between the heterocyclic nitrogen