1α, 25-Dihydroxyvitamin D3, and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta
✍ Scribed by Weisman, Y.; Harell, A.; Edelstein, S.; David, M.; Spirer, Z.; Golander, A.
- Book ID
- 109716225
- Publisher
- Nature Publishing Group
- Year
- 1979
- Tongue
- English
- Weight
- 358 KB
- Volume
- 281
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/281317a0
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Cultured microglial cells were examined for their ability to metabolize 25-hydroxyvitamin D, (25-(OH) D,). Upon exposure to lipopolysaccharide, microglial cells produced a vitamin D metabolite which comigrated with synthetic 1,25-dihydroxyvitamin D, (1,25-(OH),D,) in two different systems of high pe
## Abstract The 25‐hydroxyvitamin D~3~‐24‐hydroxylase mRNA is tightly and reciprocally regulated by 1,25‐dihydroxyvitamin D~3~ (1,25(OH)~2~D~3~) and parathyroid hormone (PTH). The upregulation of the 24‐hydroxylase by 1,25(OH)~2~D~3~ is well established and occurs at the transcriptional level throu