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Calcium regulating activity of 24a-homo-24,24-difluoro-1α,25-dihydroxyvitamin D3and 26,27-dimethyl-24,24-difluoro-1α,25-dihydroxyvitamin D3

✍ Scribed by Masahiro Harada; Tatsuro Miyahara; Masaki Miyata; Hiroko Komiyama; Akemi Sugure; Yumi Ikemoto; Sumiyo Kondo; Tadanobu Takamura; Shohei Higuchi; Susumu Otomo; Hiroshi Kozuka; Nobuo Ikekawa

Publisher
Springer
Year
1993
Tongue
English
Weight
592 KB
Volume
53
Category
Article
ISSN
1432-0827

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A series of analogs of 1 alpha,25-dihydroxyvitamin D3[1,25(OH)2D3] with alkyl substitutions in 26- and 27-positions were tested for calcium (Ca) regulating activity. The potencies of dialkyl analogs in stimulating bone resorption in neonatal mouse calvaria cultures were the highest in 1 alpha,25-dih

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## Abstract The 25‐hydroxyvitamin D~3~‐24‐hydroxylase mRNA is tightly and reciprocally regulated by 1,25‐dihydroxyvitamin D~3~ (1,25(OH)~2~D~3~) and parathyroid hormone (PTH). The upregulation of the 24‐hydroxylase by 1,25(OH)~2~D~3~ is well established and occurs at the transcriptional level throu