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1H-NMR studies on substance P hexapeptide analogs

✍ Scribed by Anthony Ribeiro; Oleg Jardetzky; Chaim Gilon; Dina Teitelbaum; Michael Chorev

Publisher: Wiley (John Wiley & Sons)
Year: 1983
Tongue: English
Weight: 323 KB
Volume: 22
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360220134

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✦ Synopsis

Synopsis

'H-nmr studies of [pG1u6]SPs~1, [gpG1u6,mPhe7]SP6 11, and [pGlu6,N-CH3Phe7]SPg~~ in DMSO-ds reveal characteristic chemical shifts, 3 5 ~~ a ~~, temperature dependence, as well as deuterium exchange half-times. Marked similarities are revealed for the two first analogs, whereas the N-methylated analog is clearly different. Possible conformations are considered.

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