The syntheses of three series of glutamate oligopeptides attached to a macromolecular solubilizing polyoxyethylene (POE) group Boc-[Glu(OMe)],-OPOE, Ac-[Glu(OMe)],-OPOE, pGlu-[Gl~(0Me)]~~,-0POE ( n = 1-7) and their various analogs specifically deuterated a t individual a-CH positions using the liqui
1H-NMR studies on poly(oxyethylene)-bound oligopeptides
✍ Scribed by Karsten Bode; Manfred Mutter; Robert P. Saltman; Murray Goodman; Anthony A. Ribeiro
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1983
- Tongue
- English
- Weight
- 267 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0006-3525
No coin nor oath required. For personal study only.
✦ Synopsis
Conformational studies on poly(oxyethy1ene)-bound homo-, oligo-, guest-host, and sequential peptides synthesized according to the liquid-phase method were carried out by means of 'H-nmr spectroscopy. The solubilizing effect of the C-terminal polymeric support allowed a thorough investigation of the secondary structure in solution.
📜 SIMILAR VOLUMES
## Abstract The use of high‐resolution nmr to determine the structure of linear homo‐oligopeptides in solution is described. Complete assignments of NH and α‐CH resonances were elucidated based upon a guest–host series of compounds and selective α‐deuteration of residues in the chain. The conformat
The use of 'H-nmr spectroscopy is demonstrated to be a useful analytical method to characterize the structure of synthetic peptides attached to soluble, macromolecular polyoxyethylene (POE) supports in the liquid-phase method (LPM) of peptide synthesis. We report an extensive 360-MHz lH-nmr study of
## Abstract ^1^H‐nmr spectra for a series of Boc‐L‐(Met)~__n__~‐OMe (__n__ = 2–9) homo‐oligopeptides have been observed in the helix‐supporting solvent trifluoroethanol (TFE) at millimolar concentrations. Interfering solvent peaks were eliminated using two decoupling frequencies to selectively remo
## Abstract A study is presented on the configuration and conformation of 2‐methylchromone‐dimer, as well as on khellin‐dimer, based on ^1^H NMR spectroscopy.
## Synopsis 'H-nmr studies of [pG1u6]SPs~1, [gpG1u6,mPhe7]SP6 11, and [pGlu6,N-CH3Phe7]SPg~~ in DMSO-ds reveal characteristic chemical shifts, 3 5 ~~ a ~~, temperature dependence, as well as deuterium exchange half-times. Marked similarities are revealed for the two first analogs, whereas the N-me