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1H and 13C NMR analyses of amiodarone, desethylamiodarone and desoxoamiodarone

✍ Scribed by Anthony A. Ribeiro; Gordon L. Jendrasiak

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
879 KB
Volume
29
Category
Article
ISSN
0749-1581

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✦ Synopsis

The 'H and I3C NMR spectra of amiodarone, a potent cardiac antiarrhythmic agent, desethylamiodarone, the main metabolite of amiodarone and desoxoamiodarone, a less toxic form of amiodarone, were assigned using a combination of NMR techniques. Methods applied include 'H-'H COSY, homonuclear Hartmann-Hahn relayed spectroscopy (HOXAHA), broadband decoupled 'H-"C chemical shift correlation, long-range 'H-I3C chemical shift correlation and selective INEPT. This combination of NMR experiments hss completed a molecular walk along the covalent framework of the cardiac drug molecules, and removed ambiguities in their 'H and 13C NMR assignments.

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