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[18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey

✍ Scribed by Eric D. Hostetler; Sandra Sanabria-Bohórquez; Hong Fan; Zhizhen Zeng; Linda Gammage; Patricia Miller; Stacey O'Malley; Brett Connolly; James Mulhearn; Scott T. Harrison; Scott E. Wolkenberg; James C. Barrow; David L. Williams Jr.; Richard J. Hargreaves; Cyrille Sur; Jacquelynn J. Cook


Book ID
116799754
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
846 KB
Volume
38
Category
Article
ISSN
0969-8051

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## Abstract Uncharged derivatives of thioflavin‐T have known __in vitro__ and __in vivo__ affinity for amyloid β. We synthesized and evaluated two derivatives with a fluorine‐18 labelled fluoropropoxy substituent either at the 6‐position or at the 2′‐position of the 2‐(4′‐aminophenyl)‐1,3‐benzothia