18F-fluorothymidine kinetics of malignant brain tumors
β Scribed by Christiaan Schiepers; Wei Chen; Magnus Dahlbom; Timothy Cloughesy; Carl K. Hoh; Sung-Cheng Huang
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 239 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0340-6997
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Radiotherapy is usually recommended for patients with a primary malignant brain tumor. The foundation for its use is grounded on the results of randomized trials for malignant gliomas which have demonstrated a relationship between survival and external beam radiation dose. Although similar trials ha
## Abstract Although 3β²βdeoxyβ3β²β[^18^F]fluorothymidine ([^18^F]FLT) is a prospective radiopharmaceutical for the imaging of proliferating tumor cell, it is difficult to prepare large amount of [^18^F]FLT. We herein describe the preparation of [^18^F]FLT in an ionic liquid, [bmim][OTf] (1βbutylβ3βm