Despite the ability of surgery, radiotherapy, and chemotherapy to prolong survival in patients with glioblastoma multiforme (GBM), most patients succumb to their disease, usually as a result of local tumor persistence or recurrence. Stereotactic radiosurgery (SRS) allows a substantial increase in to
Radiotherapy of primary malignant brain tumors
โ Scribed by David A. Larson; William M. Wara
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 54 KB
- Volume
- 14
- Category
- Article
- ISSN
- 8756-0437
No coin nor oath required. For personal study only.
โฆ Synopsis
Radiotherapy is usually recommended for patients with a primary malignant brain tumor. The foundation for its use is grounded on the results of randomized trials for malignant gliomas which have demonstrated a relationship between survival and external beam radiation dose. Although similar trials have not been performed for most other primary intracranial tumors, radiation oncologists treat them in a similar fashion, delivering the highest possible dose consistent with acceptable levels of normal tissue damage. In most cases, focal therapy is required, using modern three-dimensional treatment planning and delivery--with whole brain or craniospinal therapy used only for infrequently encountered clinical presentations. With modern planning, the volume of normal tissue subjected to possible radiation damage can be minimized. Radiation effects in normal tissues typically occur months to years after treatment.
๐ SIMILAR VOLUMES
## Background: Patients with primary malignant brain tumors (pmbt) often have neurobehavioral deficits due to the tumor, subsequent surgery, and therapies that interfere with their ability to live independently or work. previous studies have shown that such patients generally have a progressive dec
A retrospective analysis was performed on all patients diagnosed with biopsyproven extragonadal germ cell tumors at the University of Virginia (Charlottesville, VA), The Medical University of South Carolina (Charleston, SC), the Bethesda Naval Hospital (Bethesda, MD), and The Medical College of Virg
Previous prospective and retrospective trials have failed to demonstrate the best treatment approach for patients with brain metastases. As a result, fractionated whole brain radiotherapy (WBRT) has been the mainstay of treatment for several decades. However, with improved surgical techniques and th
For nearly 20 years, interstitial brachytherapy has been used as adjuvant treatment for malignant brain tumors in both prospective clinical trials and as part of standard therapy. Numerous publications analyzing the results of this treatment seem to indicate an improvement in median survival for hig