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17β-hydroxywortmannin: A potent inhibitor of bone resorption and phosphatidylinositol-3-kinase

✍ Scribed by Jeffrey A. Dodge; Henry U. Bryant; John Kim; William F. Matter; Bryan H. Norman; Usha Srinivasan; Chris J. Vlahos; Masahiko Sato

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
336 KB
Volume
5
Category
Article
ISSN
0960-894X

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✦ Synopsis

Structure-function studies on the natural product wortmannin have identified a 171~-hydroxy derivative as a potent inhibitor of osteoclast function in both cell and animal models. Mechanistic studies indicate osteoclast differentiation is dramatically affected by this class of compounds. Interestingly, comparable potency trends for resorption and phosphatidylinositol-3-kinase inhibition were also observed.

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