17Ξ²-hydroxywortmannin: A potent inhibito
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Jeffrey A. Dodge; Henry U. Bryant; John Kim; William F. Matter; Bryan H. Norman;
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Article
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1995
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Elsevier Science
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English
β 336 KB
Structure-function studies on the natural product wortmannin have identified a 171~-hydroxy derivative as a potent inhibitor of osteoclast function in both cell and animal models. Mechanistic studies indicate osteoclast differentiation is dramatically affected by this class of compounds. Interesting