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174 Processing of APP in polarized epithelial cells and neurons: relationships among cell types

✍ Scribed by B. De Strooper; D. Moechars; P. Tienari; M. Simons; K. Beyreuther; C. Dotti; F. Van Leuven


Book ID
117413866
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
276 KB
Volume
17
Category
Article
ISSN
0197-4580

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## Abstract Activation of the nuclear enzyme poly(ADP‐ribose)‐1 leads to the death of neurons and other types of cells by a mechanism involving NAD^+^ depletion and mitochondrial permeability transition. It has been proposed that the mitochondrial permeability transition (MPT) is required for NAD^+