1,6 Addition of carbanionic reagents to 10-methyl hexahydronaphthalenone

✍ Scribed by Evagelia Hatzigrigoriou; Marie-Claude Roux-Schmitt; Lya Wartski; Jacqueline Seyden-Penne

• Publisher: Elsevier Science
• Year: 1988
• Tongue: French
• Weight: 344 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)86147-0

✦ Synopsis

1.6 addition of carbanionic reagents to bicycllc dtenone I requires anlonic activation : according to the acidity ,of the corresponding carbon acids, good yields in 7d -adducts can be obtained either in THF-HMPA with nBuLi or tBuOK as bases or under solid-liquid phase transfer catalysis.