[15O]H2O, [15O]O2 and [15O]CO gas production, monitoring and quality control system
β Scribed by J.R. Jackson; B.S. Dembowski; R.L. Ehrenkaufer; E. McIntyre; M. Reivich
- Book ID
- 103989293
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 463 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0969-8043
No coin nor oath required. For personal study only.
β¦ Synopsis
The 15O gas production system selects the gas production mode, monitors gas delivery conditions and performs quality control needed during the production and delivery of continuous flow radioactive gas for equilibrium and bolus PET studies. Target gas switches choose the appropriate valve positioning for [15O]H2O, [15O]O2 or [15O]CO production while flow rate, pressure and radioactivity are constantly monitored. The system also includes an IBM PC interfaced gas chromatograph which provides chemical and radiochemical quality control by on-line, real time, gas sampling of the delivery line.
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## Abstract A general synthetic approach for the synthesis of ^15^Nβ and ^17^Oβdoubly labelled pyrimidine nucleosides is described. The ^15^N isotopes in uridine and the ^17^O isotope in the ureaβderived carbonyl group of uridine and cytidine originate from (^15^N~2~)[^17^O]urea (5) which was synth
## Abstract The 5βmethyl(^15^N~2~)[__O__^2^,__O__^4^β^17^O~2~]uridine (= (^15^N~2~)[__O__^2^,__O__^4^β^17^O ~2~]ribosylthymine; 15) was synthesized and analyzed by ^15^Nβ and ^17^OβNMR spectroscopy. (^15^N~2~)Urea was condensed with 2,3βdibromoβ2βmethylpropanoyl chloride (3) and cyclized to form (^