Production and quality control of 15O2 and C15O2 for medical use
โ Scribed by K. Strijckmans; C. Vandecasteele; J. Sambre
- Publisher
- Elsevier Science
- Year
- 1985
- Weight
- 479 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0020-708X
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๐ SIMILAR VOLUMES
## Abstract A general synthetic approach for the synthesis of ^15^Nโ and ^17^Oโdoubly labelled pyrimidine nucleosides is described. The ^15^N isotopes in uridine and the ^17^O isotope in the ureaโderived carbonyl group of uridine and cytidine originate from (^15^N~2~)[^17^O]urea (5) which was synth
## Abstract The 5โmethyl(^15^N~2~)[__O__^2^,__O__^4^โ^17^O~2~]uridine (= (^15^N~2~)[__O__^2^,__O__^4^โ^17^O ~2~]ribosylthymine; 15) was synthesized and analyzed by ^15^Nโ and ^17^OโNMR spectroscopy. (^15^N~2~)Urea was condensed with 2,3โdibromoโ2โmethylpropanoyl chloride (3) and cyclized to form (^