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15-Lox-1 inhibits P21 (Cip/WAF1) expression by enhancing Mek-Erk1/2 signaling in colon carcinoma cells

✍ Scribed by Yoshinaga, Masahiro; Dubois, Raymond N.

Book ID
123269498
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
247 KB
Volume
124
Category
Article
ISSN
0016-5085

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## Abstract The abnormal accumulation of methylglyoxal (MG), a physiological glucose metabolite, is strongly related to the development of diabetic complications by affecting the metabolism and functions of organs and tissues. These disturbances could modify the cell response to hormones and growth