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15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK1/2 signaling in colon carcinoma cells

✍ Scribed by Masahiro Yoshinaga; F.Gregory Buchanan; Raymond N. DuBois

Book ID
113864856
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
237 KB
Volume
73
Category
Article
ISSN
0090-6980

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## Abstract The abnormal accumulation of methylglyoxal (MG), a physiological glucose metabolite, is strongly related to the development of diabetic complications by affecting the metabolism and functions of organs and tissues. These disturbances could modify the cell response to hormones and growth