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14C-labelling of NNC 756, a new dopamine D1 antagonist

✍ Scribed by Christian Foged; Louis B. Hansen; Christer Halldin

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
450 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A ^14^C labelled form of (+)‐8‐chloro‐5‐(2,3‐dihydrobenzofuran‐7‐yl)‐7‐hydroxy‐3‐methyl‐2,3,4,5‐tetrahydro‐1H‐3‐benzazepine (NNC 756) (8) was synthesized in 7 steps, including resolvation of the active (+)‐form, starting from [^14^C]methyl iodide and 7‐benzofurancarbaldehyde. The overall radiochemical yield was 11%. The radiochemical purity of [4‐^14^C]NNC 756 was higher than 98% with a specific radioactivity of 24 mCi/mmol.

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