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14-Epi Stereoisomers of 25-Hydroxy- and 1.alpha.,25-Dihydroxyvitamin D3: Synthesis, Isomerization to Previtamins, and Biological Studies

✍ Scribed by Maynard, David F.; Trankle, William G.; Norman, Anthony W.; Okamura, William H.


Book ID
126923664
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
821 KB
Volume
37
Category
Article
ISSN
0022-2623

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We found a concise route to the Trost A-ring precursor enyne for synthesizing 2a-alkylated 1a,25-dihydroxyvitamin D 3 (1) from d-glucose. The enynes were coupled with the 20-epi-CD ring part to study the effect of the double modification of 2asubstitution and 20-epimerization upon biological activit