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A Practical Synthesis of 14-epi-19-nor-1α,25-Dihydroxyvitamin D3 Analogues and Their A-ring Epimers

✍ Scribed by Yusheng Wu; Yurui Zhao; Honjian Tian; Pierre De Clercq; Maurits Vandewalle; Marielle Berthier; Gills Pellegrino; Philippe Maillos; Jean-Claude Pascal


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
472 KB
Volume
2001
Category
Article
ISSN
1434-193X

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Copper-Mediated Alkylation of Vitamin D C-Ring. Synthesis of C11-Functionalized 1α,25-Dihydroxyvitamin D3. -The functionalization of C-11 of CD-ring fragments of vitamin D3, e.g. (I), with organocopper reagents is studied. The application results in an efficient, convergent synthesis of the calcitr