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1,3,4-Oxadiazole formation; a novel solid support strategy

✍ Scribed by John P Kilburn; Jesper Lau; Raymond C.F Jones

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
92 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new approach to the synthesis of 1,3,4-oxadiazoles on solid support is described. Resin bound 1-acyl thiosemicarbazides were treated with a variety of dehydrating agents at different temperatures, which revealed that thiosemicarbazides were effectively cyclised by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCβ€’HCl); mild acidic cleavage from the solid support released the substituted 1,3,4-oxadiazoles in excellent purity.

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