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1,3-Syn diastereoselective reduction of β-hydroxyketones utilizing alkoxydialkylboranes

✍ Scribed by Kau-Ming Chen; Goetz E Hardtmann; Kapa Prasad; Oljan Repič; Michael J Shapiro


Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
207 KB
Volume
28
Category
Article
ISSN
0040-4039

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✍ Yuji Mori; Miki Kuhara; Akio Takeuchi; Makoto Suzuki 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 238 KB

The diastereoselective reduction of acyclic B-alkoxy ketones with lithium aluminum hydride in the presence of lithium iodide has been studied and found to provide syn-1,3-diol derivatives with high diastereoselection. -The stereocontrolled formation of 1,3-diols is of great interest to synthetic che