The Epstein-Barr virus (EBV) is a ubiquitous Herpes virus which causes infectious mononucleosis and is associated with such different neoplasms as Burkitt's lymphoma and nasopharyngeal carcinoma. EBV latently infects its target cells; nevertheless, evidence of viral replication in NPC tumours has be
[125I] Clq-binding activity and its relationship with anti-Epstein—Barr virus antibodies in sera from nasopharyngeal carcinoma patients
✍ Scribed by J.P. Lamelin; C. Vincent; T. Souissi; J.P. Revillard
- Book ID
- 113146223
- Publisher
- Elsevier Science
- Year
- 1979
- Weight
- 636 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0014-2964
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A salt-dependent DNA polymerase activity was demonstrated in the culture of an EBV-producing, lymphoblastoid cell line (NPC-204 cells) treated with 5-iodo-2'-deoxyuridine (IUdR). There was a high frequency of levels of antibody to this enzyme in sera of patients with nasopharyngeal carcinoma (NPC).
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Nasopharyngeal carcinoma (NPC) is a malignancy closely associated with Epstein-Barr virus (EBV). It is prevalent among the Chinese of Southern China, whereas outside China, the position seems to be different. The aim of this study was to determine the distribution of EBV genotypes in the patients wi