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Antibody against epstein-barr virus dna polymerase activity in sera of patients with nasopharyngeal carcinoma

✍ Scribed by Mei-Ying Liu; Wen-Hsiang Chou; Jen-Yang Chen; Dr. Czau-Siung Yang; Louise Nutter; Mow-Ming Hsu

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
451 KB
Volume
28
Category
Article
ISSN
0146-6615

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✦ Synopsis

A salt-dependent DNA polymerase activity was demonstrated in the culture of an EBV-producing, lymphoblastoid cell line (NPC-204 cells) treated with 5-iodo-2'-deoxyuridine (IUdR). There was a high frequency of levels of antibody to this enzyme in sera of patients with nasopharyngeal carcinoma (NPC). In contrast, sera from healthy subjects had little or no neutralizing activity. The high antibody level appeared as early as stage 1 of the disease in many NPC patients. The levels of the antibody increased with the progression of the disease and declined in treated patients. The results strongly suggest that tests measuring serum antibody against EBV DNA polymerase activity can be used for early diagnosis and prognosis of NPC.

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