Synthesis and 11C-labelling of two selec
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FrΓ©dΓ©ric Dolle; Lilian Dolci; HΓ©ric Valette; Michel Bottlaender; Denis Fournier;
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Article
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1996
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John Wiley and Sons
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French
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ABT-418 ((S)-3-methyl-5-[l-methyl-2-pyrrolidinyl]isoxazole) and N-methylcytisine (N-methyl-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido-[ I,2-a][ 1,5]diazocin-8-one) are two high affinity nicotinic cholinergic agonists. ABT-418 was synthesized in 7 steps from commercially available (S)-Boc-proline in