𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 11C-labeled (S,S)-CFMME and (R)-OHDMI and their evaluation as candidate radioligands for imaging norepinephrine transporters with PET

✍ Scribed by Magnus Schou; V.W. Pike; J. Sóvágó; B. Gulyás; P. Gallagher; D. Dobson; M.W. Walter; H. Rudyk; L. Farde; C. Halldin

Book ID
118489962
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
52 KB
Volume
31
Category
Article
ISSN
1053-8119

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis and PET evaluation of (R)-[S-m
Synthesis and PET evaluation of (R)-[S-methyl-11C]thionisoxetine, a candidate radioligand for imaging brain norepinephrine transporters
✍ Magnus Schou; Victor W. Pike; Andrea Varrone; Balázs Gulyás; Lars Farde; Christe 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 164 KB

## Abstract __Introduction:__ (__R__)‐3‐(2‐(methylthio)phenoxy)‐__N__‐methyl‐3‐phenylpropan‐1‐amine [(__R__)–thionisoxetine; **1**] is a potent inhibitor of the norepinephrine transporter (NET). We aimed to label **1** with carbon‐11 (__t__~1/2~ = 20.4 min) for evaluation as a radioligand for imagi

Synthesis and biological evaluation of S
Synthesis and biological evaluation of S-[11C]methylated mercaptoimidazole piperazinyl derivatives as potential radioligands for imaging 5-HT1A receptors by positron emission tomography (PET)
✍ Raquel Garcia; Catarina Xavier; António Paulo; Isabel Santos; Torsten Kniess; R. 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 157 KB

The novel 2-mercaptoimidazole derivatives, 1-[4-((2-methoxyphenyl)-1-piperazinyl)butyl]-2-mercaptoimidazole (3) and methyl[4-((2-methoxyphenyl)-1-piperazinyl))butyl] (2-mercapto-1-methylimidazol-5-yl)methanamide ( 8), were efficiently labelled with 11 C through methylation of the thioketone function