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Synthesis and Evaluation of N -Methyl and S -Methyl 11 C-Labeled 6-Methylthio-2-(4′- N , N -dimethylamino)phenylimidazo[1,2- a ]pyridines as Radioligands for Imaging β-Amyloid Plaques in Alzheimer’s Disease

✍ Scribed by Cai, Lisheng; Liow, Jeih-San; Zoghbi, Sami S.; Cuevas, Jessica; Baetas, Cesar; Hong, Jinsoo; Shetty, H. Umesha; Seneca, Nicholas M.; Brown, Amira K.; Gladding, Robert; Temme, Sebastian S.; Herman, Mary M.; Innis, Robert B.; Pike, Victor W.

Book ID
127212950
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
383 KB
Volume
51
Category
Article
ISSN
0022-2623

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✍ Jaya Prabhakaran; Ramin V. Parsey; Vattoly J. Majo; Ronald L. Van Heertum; J. Jo 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 224 KB 👁 1 views

## Abstract 2‐(4‐Methoxyphenyl)‐__N__‐(4‐methylbenzyl)‐__N__‐(1‐methylpiperidin‐4‐yl)acetamide (AC90179, **4**), a highly potent and selective competitive 5‐HT~2A~ antagonist, was labeled by [^11^C]‐methylation of the corresponding desmethyl analogue **5** with [^11^C]methyl triflate. The precursor