111In-Labeled Lactam Bridge-Cyclized α-Melanocyte Stimulating Hormone Peptide Analogues for Melanoma Imaging
✍ Scribed by Miao, Yubin; Gallazzi, Fabio; Guo, Haixun; Quinn, Thomas P.
- Book ID
- 115488853
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 434 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1043-1802
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Six alpha-MSH(4-10) [Nle-Asp-His-D-Phe-Arg-Trp-Lys-amide] derivatives carrying 2 or 1 or no 2,3-dihydroxy-(2S)-propyl (DHP) groups on the Lys10 amino side chain were coupled to diethylene-triaminopentaacetic acid (DTPA, a chelator for 111In) in monomeric and dimeric forms and tested for their bindin
## BACKGROUND. Previous studies have shown that the compact structure of a rhenium-cyclized ␣-melanocyte-stimulating hormone peptide analog, [Cys 3,4,10 ,D- Phe 7 ]␣-MSH 3-13 , or Re-CCMSH, significantly enhanced its in vivo tumor uptake and retention. In this study, the metal chelate 1,4,7,10-tet