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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced astrogliosis does not require activation of ornithine decarboxylase

✍ Scribed by O'Callaghan, James P.; Seidler, Frederic J.


Book ID
122771877
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
405 KB
Volume
148
Category
Article
ISSN
0304-3940

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP