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[1-(3,5-Difluoro-4-hydroxyphenyl)-1 H -pyrrol-3-yl]phenylmethanone as a Bioisostere of a Carboxylic Acid Aldose Reductase Inhibitor

✍ Scribed by Nicolaou, Ioannis; Zika, Chariklia; Demopoulos, Vassilis J.


Book ID
126023958
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
52 KB
Volume
47
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Synthesis and Biolo
✍ Simona Rapposelli; Frederico Da Settimo; Maria Digiacomo; Concettina La Motta; A πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons βš– 62 KB πŸ‘ 1 views

## Abstract A series of the title spirocyclic benzopyran derivatives (XI) (12 examples) is synthesized, which all prove to be selective inhibitors of aldose reductase (ARL2).