Effect of a new aldose reductase inhibit
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R. Kikkawa; I. Hatanaka; H. Yasuda; N. Kobayashi; Y. Shigeta; H. Terashima; T. M
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Article
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1983
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Springer
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English
โ 270 KB
A new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) was administered orally to streptozotocin-diabetic rats (60 mg/kg IV) for 14 days and its effect on motor nerve conduction velocity studied. The compound significantly improved motor nerve