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Effect of a potent new aldose reductase inhibitor, (5-(3-thienyl)tetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats

โœ Scribed by N. Hotta; H. Kakuta; H. Fukasawa; N. Koh; F. Sakakibara; J. Nakamura; Y. Hamada; T. Wakao; T. Kara; K. Mori; K. Naruse; E. Nakashima; S. Inukai; N. Sakamoto


Book ID
119135637
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
878 KB
Volume
27
Category
Article
ISSN
0168-8227

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A new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) was administered orally to streptozotocin-diabetic rats (60 mg/kg IV) for 14 days and its effect on motor nerve conduction velocity studied. The compound significantly improved motor nerve