1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as Potent Factor Xa Inhibitors. Part 2. A Survey of P4 Motifs.

1-(2-Naphthyl)-1H-pyrazole-5-carboxylami

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as Potent Factor Xa Inhibitors. Part 3. Design, Synthesis and SAR of Orally Bioavailable Benzamidine-P4 Inhibitors.

✍ Zhaozhong J. Jia; Bing-Yan Zhu; et al. et al. 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 81 KB 👁 1 views

ChemInform Abstract: Design, Synthesis a

ChemInform Abstract: Design, Synthesis and Discovery of 1-(2-(6-Chloro-3-methylsulfonyl)-naphthyl)-1H-pyrazole-5-carboxylamides as Highly Potent Factor Xa Inhibitors.

✍ Zhaozhong Jon Jia; Robert Murry Scarborough; Penglie Zhang; Sherin Halfon; Ann E 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

Synthesis and Evaluation of 1-Arylsulfon

Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors. Part 5. A Series of New Derivatives Containing a Spiro[imidazo[1,2-a]pyrazine-2(3H),4′-piperidin]-5(1H)-one Scaffold.

✍ Fumihiko Saitoh; et al. et al. 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 28 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Synthesis and Evaluation of 1-Arylsulfon

Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors. Part 4. A Series of New Derivatives Containing a Spiro[5H-oxazolo[3,2-a]pyrazine-2(3H),4′-piperidin]-5-one Skeleton.

✍ Hidemitsu Nishida; et al. et al. 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 136 KB 👁 1 views

5-Heteroatom Substituted Pyrazoles as Ca

5-Heteroatom Substituted Pyrazoles as Canine COX-2 Inhibitors. Part 1. Structure—Activity Relationship Studies of 5-Alkylamino Pyrazoles and Discovery of a Potent, Selective, and Orally Active Analogue.

✍ Subas M. Sakya; et al. et al. 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 23 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

ChemInform Abstract: Discovery of a Fact

ChemInform Abstract: Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic Acid 3-[(5-Chloro-pyridin-2-yl)-amide] 4-{[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a Clinical Candidate.

✍ Wolfgang Haap; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 23 KB 👁 1 views

## Abstract Compound (I) is found to be a potent, selective and orally bioavailable fXa inhibitor based on a pyrrolidine scaffold.