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μ-Opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPγS binding assays

✍ Scribed by Árpád Márki; Krisztina Monory; Ferenc Ötvös; Géza Tóth; Roland Krassnig; Helmut Schmidhammer; John R Traynor; Bernard P Roques; Rafael Maldonado; Anna Borsodi


Book ID
114017537
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
114 KB
Volume
383
Category
Article
ISSN
0014-2999

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We utilized the [ 35 S]-GTP-␥-S functional binding assay to determine the selectivity of opioid receptor agonists in guinea pig caudate membranes. The study focused on two opioid agonists used for treating opioid-dependent patients: methadone and buprenorphine. Selective antagonists were used to gen