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β,β-Dimethylacrylshikonin exerts antitumor activity via Notch-1 signaling pathway in vitro and in vivo

✍ Scribed by Shao Zhen-Jun; Zhang Yuan-Yuan; Fan Ying-Ying; Jin Shao-Ju; Yan Jiao; Zheng Xiao-Wei; Chen Jian; Xiong Yao; Zhou Li-Ming


Book ID
113489778
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
778 KB
Volume
84
Category
Article
ISSN
0006-2952

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## Abstract Dysregulation of the ubiquitin‐proteasome pathway plays an essential role in tumor growth and development. Shikonin, a natural naphthoquinone isolated from the traditional Chinese medicine __Zi Cao__ (__gromwell__), has been reported to possess tumor cell‐killing activity, and results f