Parathyroid Hormone Regulates Transforming Growth Factor β1 and β2 Synthesis in Osteoblasts Via Divergent Signaling Pathways
✍ Scribed by Yanhong Wu; Rajiv Kumar
- Book ID
- 111486757
- Publisher
- American Society for Bone and Mineral Research
- Year
- 2010
- Tongue
- English
- Weight
- 201 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0884-0431
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## Abstract Parathyroid hormone (PTH) regulates bone remodeling and calcium homeostasis by acting on osteoblasts. Recently, the gene expression profile changes in the rat PTH (1–34, 10^−8^M)‐treated rat osteoblastic osteosarcoma cell line, UMR 106‐01, using DNA microarray analysis showed that mRNA
## Abstract Parathyroid hormone (PTH) exerts an anabolic action on bone but the mechanisms are incompletely understood. We showed previously that PTH interacts with the canonical Wnt‐β‐catenin signaling pathway via the transforming growth factor (TGF)‐β signaling molecule, Smad3, to modulate osteob