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β2-Microglobulin Induces Stromelysin Production by Human Synovial Fibroblasts

✍ Scribed by Kiyoshi Migita; Katsumi Eguchi; Masahiro Tominaga; Tomoki Origuchi; Yojiro Kawabe; Shigenobu Nagataki

Book ID: 115580928
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 232 KB
Volume: 239
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1997.7366

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The authors have shown that the interferon inducer, double-stranded polynucleotide, poly I poly C, and human interferon stimulate prostaglandin E (PGE) (1) and hyaluronic acid (HA) production (2) in human synovial fibroblast cultures and induce inflammation when injected into the rat joint ( 3 ) . A