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β1Integrins Mediate Mechanosensitive Signaling Pathways in Osteocytes

✍ Scribed by Julie B. Litzenberger; Jae-Beom Kim; Padmaja Tummala; Christopher R. Jacobs

Book ID
105913830
Publisher
Springer
Year
2010
Tongue
English
Weight
374 KB
Volume
86
Category
Article
ISSN
1432-0827

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Ras is activated by transforming growth factor beta (TGF␤) in several cell types, but the biological consequences of this activation are largely unknown. We now show that ras mediates two stages in integrin ␤1-chain maturation: 1) glycosylation of the 86-kD core peptide, which is a TGF␤1-independent