β1-Integrins Mediate Ca2+-Signalling and T Cell Spreading via Divergent Pathways
✍ Scribed by Hella Schöttelndreier; Georg W Mayr; Andreas H Guse
- Book ID
- 114284220
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 632 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0898-6568
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## Abstract Calcium‐regulated non‐receptor proline‐rich tyrosine kinase 2 (Pyk2) is a critical mediator of endothelin‐1 (ET‐1) signaling in human glomerular mesangial cells (GMC). We aimed to identify which small G‐protein is acting downstream of Pyk2. Dominant interfering Pyk2 construct, termed ca