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β-Sheet-breaking peptides inhibit the fibrillation of human α-synuclein

✍ Scribed by You Soon Kim; Dongyeol Lim; Joo Yeon Kim; Shin Jung Kang; Yang-Hee Kim; Hana Im


Book ID
116298952
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
603 KB
Volume
387
Category
Article
ISSN
0006-291X

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## Abstract Abnormal protein aggregation in the brain is linked to the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Recent studies revealed that the oligomeric form of aggregates is most likely the toxic species, and thus could be a go