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β-pyridylacrylophenones and analogs. New class of active coronary dilating agents

✍ Scribed by John Koo

Publisher: John Wiley and Sons
Year: 1964
Tongue: English
Weight: 414 KB
Volume: 53
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600531109

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✦ Synopsis

A series of &pyridylacrylophenones and closely related analogs was synthesized by the condensation of yridinecarboddehydes and other heterocyclic aldehydes with ap ropriate acetop E enones in the presence of various catalysts. The proportions opvuious reaction products depended upon catalyst and reaction conditions. Several compounds of thu ty e bave been found pharmacologically to exhibit re-mUh%le coronary dilating activity.

ANY CHROMONE derivatives exhibit interesting pharmacological activites. Khellin has long been used as a vasodilator (1, 2); recently, some 5,8-dimethoxychromone derivatives were found to exert a powerful coronary dilating (3) or central nervous system depressing action (4). Also, it has been reported (5, 6) that flavonoids possess the ability to form chalcones under certain biological conditions.

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