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Synthesis and Structure-Activity Relationship of Some New β-Blocking Agents with Possible α-Adrenoreceptor Activity

✍ Scribed by JáNos Bergmann; KáLmáN Takács

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
389 KB
Volume
323
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

A series of new phenoxypropanolamines with cyclic guanidine and isothiourea moieties has been prepared and investigated for non‐specific α‐ and α‐adrenoreceptor activity by receptor binding experiments on crude rat brain membrane. Some of them [9a, 10c] possess affinity for both β‐ and α‐adrenoreceptors.

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## Structure-Activity Relationships of Some 1,4-Benzodioxane Arylpiperazine Derivatives as α-Blocking Agents. -A series of novel 1,4-benzodioxane derivatives (III) (8 examples) are synthesized and evaluated for their blocking activity on α-adrenoceptors. Structure-activity relationships are discu