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β-phenylpyruvate and glucose uptake in isolated mouse soleus muscle and cultured C2C12 muscle cells

✍ Scribed by Ron Ben-Abraham; Vered Gazit; Oded Vofsi; Izahar Ben-Shlomo; Abraham Z. Reznick; Yeshayahu Katz

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
104 KB
Volume
90
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Previous investigation demonstrated the potential of β‐phenylpyruvate at high concentration to cause hypoglycemia in mice totally deprived of insulin. For further elucidation of the glucose‐lowering mechanism, glucose uptake, and quantity of glucose transporters (GLUT1 and GLUT4) in mouse soleus muscle and C2C12 muscle cell lines were investigated following incubation with β‐phenylpyruvate in various concentrations. A marked enhancement of glucose uptake was demonstrated that peaked at 0.5 and 1.0 mM β‐phenylpyruvate in soleus muscle (P < 0.01) and C2C12 cells (P < 0.001), respectively. Kinetic analysis in C2C12 cells showed a twofold increase in V~max~ compared with controls (P < 0.001). In addition, both GLUT1 and GLUT4 levels were increased following exposure to β‐phenylpyruvate. Our findings point to a peripheral hypoglycemic effect of β‐phenylpyruvate. © 2003 Wiley‐Liss, Inc.

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